Helios Should Not Be Cited as a Marker of Human Thymus-Derived Tregs. Commentary: Helios+ and Helios− Cells Coexist within the Natural FOXP3+ T Regulatory Cell Subset in Humans
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چکیده
Citation: Elkord E (2016) Helios Should Not Be Cited as a Marker of Human Thymus-Derived Tregs. Commentary: Helios and Helios− Cells Coexist within the Natural FOXP3+ T Regulatory Cell Subset in Humans. Front. Immunol. 7:276. doi: 10.3389/fimmu.2016.00276 Helios Should not Be Cited as a marker of Human thymus-Derived tregs. Commentary: Helios+ and Helios− Cells Coexist within the natural FoXP3+ t regulatory Cell Subset in Humans
منابع مشابه
Helios Expression Is a Marker of T Cell Activation and Proliferation
Foxp3+ T-regulatory cells (Tregs) normally serve to attenuate immune responses and are key to maintenance of immune homeostasis. Over the past decade, Treg cells have become a major focus of research for many groups, and various functional subsets have been characterized. Recently, the Ikaros family member, Helios, was reported as a marker to discriminate naturally occurring, thymic-derived Tre...
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Helios is a member of the Ikaros transcription factor family and has been reported to be a marker of thymus-derived regulatory T cells (Treg). Helios is an intracellular protein, however, and hence cannot be used as a marker to separate living Tregs. To solve this problem, we generated Helios reporter mice in which Helios+ cells selectively express Venus, a variant of green fluorescent protein....
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Foxp3(+) regulatory T cells (Tregs) maintain self-tolerance and adoptive therapy, and using Foxp3(+) Tregs has been proposed as treatment for autoimmune diseases. The clinical use of Tregs will require large numbers of cells and methods for in vitro expansion of Tregs are being developed. Foxp3(+) Tregs can be divided into 2 subpopulations based on expression of the transcription factor, Helios...
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